"On water" nano-Cu2O-catalyzed CO-free one-pot multicomponent cascade cyanation–annulation–aminolysis reaction toward phthalimides. Issue 8 (5th February 2021)

• Record Type: Journal Article
• Authors: Wen, Xiaowei; Liu, Xiaojuan; Yang, Zhiqi; Xie, Menglan; Liu, Yuxi; Long, Lipeng; Chen, Zhengwang
• Is Part Of: Organic & biomolecular chemistry. Volume 19:Issue 8(2021)
• Page Start: 1738
• Page End: 1743
• Publication Date: 2021-02-05
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d1ob00073j
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : An efficient nano-Cu2 O-catalyzed CO-free reaction toward phthalimides from 2-halobenzoic acids, TMSCN and amines "on water". Abstract : An efficient nano-Cu2 O-catalyzed cascade multicomponent reaction of 2-halobenzoic acids and trimethylsilyl cyanide with diverse amines was developed using water as a solvent, affording versatile N -substituted phthalimide derivatives in moderate to excellent yields. This novel strategy features carbon monoxide gas-free, environmentally benign, one-pot multistep transformation, commercially available reagents, a cheap catalyst without any additives, wide functional group tolerance, and operational convenience.