Total synthesis of landomycins Q and R and related core structures for exploration of the cytotoxicity and antibacterial properties. Issue 16 (2nd March 2021)

• Record Type: Journal Article
• Authors: Lai, Yao-Hsuan; Mondal, Soumik; Su, Hsin-Tzu; Huang, Sheng-Cih; Wu, Mine-Hsine; Huang, I.-Wen; Yang Lauderdale, Tsai-Ling; Song, Jen-Shin; Shia, Kak-Shan; Mong, Kwok-Kong Tony
• Is Part Of: RSC advances. Volume 11:Issue 16(2021)
• Page Start: 9426
• Page End: 9432
• Publication Date: 2021-03-02
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/d1ra01088c
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Herein, we report the total synthesis of landomycins Q and R as well as the aglycone core, namely anhydrolandomycinone and a related core analogue. Abstract : Herein, we report the total synthesis of landomycins Q and R as well as the aglycone core, namely anhydrolandomycinone and a related core analogue. The synthesis features an acetate-assisted arylation method for construction of the hindered B-ring in the core component and a one-pot aromatization–deiodination–denbenzylation procedure to streamline the global functional and protecting group manuipulation. Subsequent cytotoxicity and antibacterial studies revealed that the landomycin R is a potential antibacterial agent against methicillin-resistant Staphylococcus aureus .