Sodium butyrate selectively inhibits host cell glycoprotein synthesis in human fibroblasts infected with cytomegalovirus. Issue 7 (July 1985)

• Record Type: Journal Article
• Authors: Radsak, K.; Wiegandt, H.; Unterdörfer, G.; Wagner, C.; Kaiser, C. J.
• Is Part Of: Bioscience reports. Volume 5:Issue 7(1985)
• Page Start: 589
• Page End: 599
• Publication Date: 1985-07
• Subjects: Molecular biology -- Periodicals; Cytology -- Periodicals; 572.8
• DOI: 10.1007/BF01117072
• Languages: English
• ISSNs: 0144-8463

Abstract

Abstract : Host cell as well as viral DNA synthesis in human fibroblasts infected with human cytomegalovirus was found to be largely resistant even to high concentrations sodium butyrate. Likewise, production of viral progeny was reduced by 1–2 orders of magnitude but not abolished. On the other hand, the drug allowed (modified) glycosylation only of viral polypeptides whereas that of host proteins was suppressed. Immunofluorescence studies on living cells suggested that butyrate may interfere with processing and intracellular transport of virus-specific surface membrane antigens.