Comparative Analysis of Capillary vs Venous Blood for Serologic Detection of SARS-CoV-2 Antibodies by RPOC Lateral Flow Tests. (28th January 2021)

• Record Type: Journal Article
• Authors: Morshed, Muhammad; Sekirov, Inna; McLennan, Meghan; Levett, Paul N; Chahil, Navdeep; Mak, Annie; Carruthers, Erin; Pidduck, Tamara; Kustra, Jesse; Laley, Jonathan; Lee, Min-Kuang; Chu, Kenneth; Burgess, Fred; Vijh, Rohit; Willis, Lori; Wada, Ray; Blancaflor, Rosemarie; Boraston, Suni; Hayden, Althea; Krajden, Mel
• Is Part Of: Open forum infectious diseases. Volume 8:Number 3(2021)
• Publication Date: 2021-01-28
• Subjects: COVID-19 -- diagnostic microbiology -- public health -- rapid point-of-care test -- serology; Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofab043
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: A comparison of rapid point-of-care serology tests using finger prick and venous blood was done on 278 participants. In a laboratory setting, immunoglobulin G (IgG) sensitivity neared 100%; however, IgG sensitivity dramatically dropped (82%) in field testing. Possible factors include finger prick volume variability, hemolysis, cassette readability, and operator training.