EBF recommendation on the validation of bioanalytical methods for dried blood spots. (July 2011)

• Record Type: Journal Article
• Authors: Timmerman, Philip; White, Steve; Globig, Susanne; Lüüdtke, Silke; Brunet, Leonarda; Smeraglia, John
• Is Part Of: Bioanalysis. Volume 3:Number 14(2011)
• Page Start: 1567
• Page End: 1575
• Publication Date: 2011-07
• Subjects: Drugs -- Analysis -- Periodicals; 615.19005
• DOI: 10.4155/bio.11.132
• Languages: English
• ISSNs: 1757-6180

Abstract

Over the last few years bioanalysts, pharmacokineticists and clinical investigators have rediscovered the technique of dried blood spots. The revival has provided pharmaceutical R&D a wealth of opportunities to optimize the drug-discovery and development process with respect to animal and patient ethics, new scientific insights and costs savings. On the bioanalytical front, multiple experiments have been performed and a lot of experience has been gained. Nevertheless, the technique still has a number of bioanalytical challenges. The European Bioanalysis Forum discussed the advantages and hurdles of the technique and summarized their current thinking in a recommendation on the validation of bioanalytical methods for dried blood spots, which can be used as a cornerstone for further discussions and experiments.