The cytotoxic mechanisms of disulfiram and copper(ii) in cancer cells. Issue 6 (10th September 2015)

• Record Type: Journal Article
• Authors: Tawari, Patricia Erebi; Wang, Zhipeng; Najlah, Mohammad; Tsang, Chi Wai; Kannappan, Vinodh; Liu, Peng; McConville, Christopher; He, Bin; Armesilla, Angel L.; Wang, Weiguang
• Is Part Of: Toxicology research. Volume 4:Issue 6(2015:Nov.)
• Page Start: 1439
• Page End: 1442
• Publication Date: 2015-09-10
• Subjects: Toxicology -- Periodicals; 615.9005
• DOI: 10.1039/c5tx00210a
• Languages: English
• ISSNs: 2045-452X

Abstract

Graphical Abstract: Abstract: The anticancer activity of disulfiram (DS) is copper(ii ) (Cu)-dependent. This study investigated the anticancer mechanisms of DS/Cu using in vitro cytotoxicity and metabolic kinetic analysis. Our study indicates that DS/Cu targets cancer cells by the combination of two types of actions: (1) instant killing executed by DS/Cu reaction generated reactive oxygen species; (2) delayed cytotoxicity introduced by the end product, DDC-Cu. Nanoencapsulation of DS might shed light on repositioning of DS into cancer treatment.