Extreme hypofractionation for prostate cancer. Issue 1 (January 2009)

• Record Type: Journal Article
• Authors: Lee, W Robert
• Is Part Of: Expert review of anticancer therapy. Volume 9:Issue 1(2009)
• Page Start: 61
• Page End: 65
• Publication Date: 2009-01
• Subjects: high-dose-rate brachytherapy -- hypofractionation -- prostate cancer -- radiotherapy -- stereotactic radiotherapy; Cancer -- Treatment -- Periodicals; 616.99406
• DOI: 10.1586/14737140.9.1.61
• Languages: English
• ISSNs: 1473-7140

Abstract

In ideal circumstances the fractionation schedule of radiotherapy should match the fractionation sensitivity of the tumor relative to the nearby normal tissues. A number of recent publications have suggested that the α/ββ ratio for prostate tumors is low – in the range of 1–3 Gy. In fact, if α/ββ is low, then hypofractionated schedules using fewer, larger fractions should improve the therapeutic ratio. This critical article examines two methods that represent schedules at the extreme end of the fractionation spectrum (3–5 fractions): high-dose-rate brachytherapy as monotherapy and stereotactic body radiotherapy.