Noninvasive Prenatal Testing as Compared to Chorionic Villus Sampling Is More Sensitive for the Detection of Confined Placental Mosaicism Involving the Cytotrophoblast. Issue 2 (February 2021)

• Record Type: Journal Article
• Authors: Van Opstal, Diane; Eggenhuizen, Geerke M.; Joosten, Marieke; Diderich, Karin; Govaerts, Lutgarde; Galjaard, Robert-Jan; Go, Attie; Knapen, Maarten; Boter, Marjan; Cheung, Wai Y.; van Koetsveld, Nicole; van Veen, Stefanie; de Valk, Walter G.; Jehee, Fernanda; de Vries, Femke; Hollink, Iris; Hoefsloot, Lies; Srebniak, Malgorzata
• Is Part Of: Obstetrical & gynecological survey. Volume 76:Issue 2(2021)
• Publication Date: 2021-02
• Subjects: Obstetrics -- Periodicals; Gynecology -- Periodicals; Generative organs, Female -- Surgery -- Periodicals; 618
• DOI: 10.1097/01.ogx.0000733524.21362.2c
• Languages: English
• ISSNs: 0029-7828

Abstract

Abstract : (Abstracted from Prenat Diagn 2020;40:1338–1342) Confined placental mosaicism (CPM) describes a chromosomally abnormal placenta with a chromosomally normal fetus. Confined prenatal mosaicism may be detected prenatally by either chorionic villus sampling (CVS) or noninvasive prenatal testing (NIPT) using cell-free DNA (cfDNA), which evaluates the DNA released from cytotrophoblast (CTB) into maternal blood.