Therapeutic strategies of iron-based nanomaterials for cancer therapy. (3rd March 2021)

• Record Type: Journal Article
• Authors: Wu, Xiaqing; Zhang, Haiyuan
• Is Part Of: Biomedical materials. Volume 16:Number 3(2021)
• Publication Date: 2021-03-03
• Subjects: iron-based nanomaterial -- cancer therapy -- immunotherapy -- ferroptosis -- magnetic therapy; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1088/1748-605X/abd0c4
• Languages: English
• ISSNs: 1748-6041

Abstract

Abstract: Iron-based nanomaterials have appeared in various cancer treatments owing to their promising functions and safety. Various sophisticated iron-based nanomaterials have been designed to exhibit great therapeutic effects through different strategies. Given the rapid progression, there is a great need to integrate the recent advances to learn about the latest innovation in this field. In this review, we classified the strategies of iron-based nanomaterials for cancer treatment into the following categories: immunotherapy, ferroptosis, magnetic hyperthermia and magneto-mechanical destruction. On the one hand, we discussed the underlining mechanism of iron-based nanomaterials in these therapies and applications; on the other hand, we analyzed the feasible combination of these applications and other therapies. Finally, the current challenges and expectation of iron-based nanomaterials in this field were highlighted.