Risk of Celiac Disease in the First‐ and Second‐Degree Relatives of Patients With Celiac Disease: A Systematic Review and Meta‐Analysis. (November 2015)

• Record Type: Journal Article
• Authors: Singh, Prashant; Arora, Shubhangi; Lal, Suman; Strand, Tor A; Makharia, Govind K
• Is Part Of: American journal of gastroenterology. Volume 110:Number 11(2015)
• Publication Date: 2015-11
• Subjects: Stomach -- Diseases -- Periodicals; Intestines -- Diseases -- Periodicals; Gastroenterology -- Periodicals; Gastrointestinal Diseases -- Periodicals; Electronic journals; Periodicals; 616.33
• DOI: 10.1038/ajg.2015.296
• Languages: English
• ISSNs: 0002-9270

Abstract

Abstract : OBJECTIVES: First‐degree relatives (FDRs) of patients with celiac disease (CD) are at high risk for CD and prevalence among them varies from 1.6 to 38%. The risk of having CD among FDRs if the FDR is sister, brother, mother, father, son, or daughter of index patient with CD is not known. We conducted a meta‐analysis and calculated pooled prevalence of CD among FDRs, second‐degree relatives (SDRs), and specific relations with index patient. METHODS: On search of literature, 2, 259 articles appeared of which 54 articles were included in this meta‐analysis. Diagnosis of CD was based on standard criteria. RESULTS: Pooled prevalence of CD was 7.5% (95% confidence interval (CI) 6.3%, 8.8%) in 10, 252 FDRs and 2.3% (95% CI 1.3%, 3.8%) in 642 SDRs. Pooled prevalence of CD was highest in siblings (8.9%), followed by offsprings (7.9%) and parents (3.0%). Female FDRs had higher prevalence than male FDRs (8.4% vs. 5.2%, P =0.047). While sisters and daughters of index patient had the highest risk of having CD (1 in 7 and 1 in 8, respectively), the risk was 1 in 13 in sons, 1 in 16 in brothers, 1 in 32 in mothers, and 1 in 33 in fathers. There were also differences in the pooled prevalence of CD in FDRs according to their geographic location. CONCLUSIONS: Pooled prevalence of CD among FDRs is 7.5% and varies considerably with their relationship with the index patient. The risk of CD in FDRs also varies according to gender and geographical location.