Recommendation for the contouring of limbic system in patients receiving radiation treatment: A pictorial review for the everyday practice and education. (March 2021)

• Record Type: Journal Article
• Authors: Sorce, Claudia; Chalaszczyk, Agnieszka; Rossi, Francesca; Ferella, Letizia; Grimaldi, Gianmarco; Splendiani, Alessandra; Genovesi, Domenico; Marampon, Francesco; Orlandi, Ester; Iannalfi, Alberto; Masciocchi, Carlo; Gravina, Giovanni Luca
• Is Part Of: Critical reviews in oncology/hematology. Volume 159(2021)
• Publication Date: 2021-03
• Subjects: Radiotherapy -- Oncology -- Limbic system -- Toxicity -- Contorting atlas -- Education; Oncology -- Periodicals; Hematology -- Periodicals; 616.994
• DOI: 10.1016/j.critrevonc.2021.103229
• Languages: English
• ISSNs: 1040-8428

Abstract

Abstract: Aims: The limbic circuit (LC) is devoted to linking emotion to behavior and cognition. The injury this system results in post-RT cognitive dysfunction. The aim of this study is to create the first radiation oncologist's practical MR-based contouring guide for the delineation of the LC for the everyday clinical practice and education. Methods: An anonymized diagnostic 3.0 T T1-weighted BRAVO MRI sequence from a healthy patient with typical brain anatomy was used to delineate LC. For each structure key anatomical contours were completed by radiation oncologists, along with a neuro-radiologist to generate the final version of the LC atlas. Results: a step-by-step MR-based atlas of LC was created. Key structures of the LC, such as, cingulate gyrus, fornix, septal region, mammillary bodies, thalamus and the hippocampal-amygdala formation were contoured. Conclusions: This article provides the recommendations for the first contouring atlas of LC in the setting of patients receiving RT and education.