Engineered nanoparticles for imaging and drug delivery in colorectal cancer. (February 2021)

• Record Type: Journal Article
• Authors: Pavitra, Eluri; Dariya, Begum; Srivani, Gowru; Kang, Sung-Min; Alam, Afroz; Sudhir, Putty-Reddy; Kamal, Mohammad Amjad; Raju, Ganji Seeta Rama; Han, Young-Kyu; Lakkakula, Bhaskar Venkata Kameswara Subrahmanya; Nagaraju, Ganji Purnachandra; Huh, Yun Suk
• Is Part Of: Seminars in cancer biology. Volume 69(2021)
• Page Start: 293
• Page End: 306
• Publication Date: 2021-02
• Subjects: AuNPs gold nanoparticles -- CEA carcino embryonic antigen -- CLM colorectal liver metastasis -- DOX doxorubicin -- DPYD dihydropyrimidine dehydrogenase -- EPR enhanced permeability and retention -- hENT1 human equilibrative nucleoside transporter 1 -- HPβCD hydroxypropyl β-cyclodextrin -- ICD immunogenic cell death -- IDO indoleamine 2, 3-dioxygenase -- ITM immunosuppressive microenvironment of tumor -- isoCA-4 isocombretastatin A-4 -- LbL layer-by-layer carrier system -- LCL long circulating liposome -- LDH layered double hydroxide -- MCM mobil composition of matter -- MDR multidrug resistance -- MDT magnetic drug targeting -- MSN mesoporous silica nanoparticle -- MUC mucin -- NPs nanoparticles -- PCL poly capro lactone -- PDL programmed cell death ligand -- PDT photodynamic therapy -- pDNA plasmid DNA -- PEG polyethylene glycol -- PLGA poly lactic-co-glycolic acid -- PNA peanut agglutinin -- PTT photothermal therapy -- QD quantum dots -- SERS surface enhanced Raman spectroscopy -- SLN solid lipid nanoparticle -- SQ squalene -- VEGF vascular endothelial growth factor; Colorectal cancer -- Chemotherapy -- Nanoparticle -- Imaging -- Drug delivery; Cancer -- Periodicals; Neoplasms -- Periodicals; Review Literature; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.semcancer.2019.06.017
• Languages: English
• ISSNs: 1044-579X

Abstract

Highlights: We review the uses of nanoparticles for CRC imaging. We discuss the uses of nanoparticles for drug delivery in CRC. We explore novel nanoparticle-based approaches for CRC treatment. We review the applications of nanoparticles to immunotherapy against CRC. Abstract: Colorectal cancer (CRC) is one of the deadliest diseases worldwide due to a lack of early detection methods and appropriate drug delivery strategies. Conventional imaging techniques cannot accurately distinguish benign from malignant tissue, leading to frequent misdiagnosis or diagnosis at late stages of the disease. Novel screening tools with improved accuracy and diagnostic precision are thus required to reduce the mortality burden of this malignancy. Additionally, current therapeutic strategies, including radio- and chemotherapies carry adverse side effects and are limited by the development of drug resistance. Recent advances in nanotechnology have rendered it an attractive approach for designing novel clinical solutions for CRC. Nanoparticle-based formulations could assist early tumor detection and help to overcome the limitations of conventional therapies including poor aqueous solubility, nonspecific biodistribution and limited bioavailability. In this review, we shed light on various types of nanoparticles used for diagnosis and drug delivery in CRC. In addition, we will explore how these nanoparticles can improve diagnostic accuracy and promote selective drug targeting to tumor sites with increased efficiency and reduced cytotoxicity against healthy colon tissue.