Engineered nanoparticles for imaging and drug delivery in colorectal cancer. (February 2021)
- Record Type:
- Journal Article
- Title:
- Engineered nanoparticles for imaging and drug delivery in colorectal cancer. (February 2021)
- Main Title:
- Engineered nanoparticles for imaging and drug delivery in colorectal cancer
- Authors:
- Pavitra, Eluri
Dariya, Begum
Srivani, Gowru
Kang, Sung-Min
Alam, Afroz
Sudhir, Putty-Reddy
Kamal, Mohammad Amjad
Raju, Ganji Seeta Rama
Han, Young-Kyu
Lakkakula, Bhaskar Venkata Kameswara Subrahmanya
Nagaraju, Ganji Purnachandra
Huh, Yun Suk - Abstract:
- Highlights: We review the uses of nanoparticles for CRC imaging. We discuss the uses of nanoparticles for drug delivery in CRC. We explore novel nanoparticle-based approaches for CRC treatment. We review the applications of nanoparticles to immunotherapy against CRC. Abstract: Colorectal cancer (CRC) is one of the deadliest diseases worldwide due to a lack of early detection methods and appropriate drug delivery strategies. Conventional imaging techniques cannot accurately distinguish benign from malignant tissue, leading to frequent misdiagnosis or diagnosis at late stages of the disease. Novel screening tools with improved accuracy and diagnostic precision are thus required to reduce the mortality burden of this malignancy. Additionally, current therapeutic strategies, including radio- and chemotherapies carry adverse side effects and are limited by the development of drug resistance. Recent advances in nanotechnology have rendered it an attractive approach for designing novel clinical solutions for CRC. Nanoparticle-based formulations could assist early tumor detection and help to overcome the limitations of conventional therapies including poor aqueous solubility, nonspecific biodistribution and limited bioavailability. In this review, we shed light on various types of nanoparticles used for diagnosis and drug delivery in CRC. In addition, we will explore how these nanoparticles can improve diagnostic accuracy and promote selective drug targeting to tumor sites withHighlights: We review the uses of nanoparticles for CRC imaging. We discuss the uses of nanoparticles for drug delivery in CRC. We explore novel nanoparticle-based approaches for CRC treatment. We review the applications of nanoparticles to immunotherapy against CRC. Abstract: Colorectal cancer (CRC) is one of the deadliest diseases worldwide due to a lack of early detection methods and appropriate drug delivery strategies. Conventional imaging techniques cannot accurately distinguish benign from malignant tissue, leading to frequent misdiagnosis or diagnosis at late stages of the disease. Novel screening tools with improved accuracy and diagnostic precision are thus required to reduce the mortality burden of this malignancy. Additionally, current therapeutic strategies, including radio- and chemotherapies carry adverse side effects and are limited by the development of drug resistance. Recent advances in nanotechnology have rendered it an attractive approach for designing novel clinical solutions for CRC. Nanoparticle-based formulations could assist early tumor detection and help to overcome the limitations of conventional therapies including poor aqueous solubility, nonspecific biodistribution and limited bioavailability. In this review, we shed light on various types of nanoparticles used for diagnosis and drug delivery in CRC. In addition, we will explore how these nanoparticles can improve diagnostic accuracy and promote selective drug targeting to tumor sites with increased efficiency and reduced cytotoxicity against healthy colon tissue. … (more)
- Is Part Of:
- Seminars in cancer biology. Volume 69(2021)
- Journal:
- Seminars in cancer biology
- Issue:
- Volume 69(2021)
- Issue Display:
- Volume 69, Issue 2021 (2021)
- Year:
- 2021
- Volume:
- 69
- Issue:
- 2021
- Issue Sort Value:
- 2021-0069-2021-0000
- Page Start:
- 293
- Page End:
- 306
- Publication Date:
- 2021-02
- Subjects:
- AuNPs gold nanoparticles -- CEA carcino embryonic antigen -- CLM colorectal liver metastasis -- DOX doxorubicin -- DPYD dihydropyrimidine dehydrogenase -- EPR enhanced permeability and retention -- hENT1 human equilibrative nucleoside transporter 1 -- HPβCD hydroxypropyl β-cyclodextrin -- ICD immunogenic cell death -- IDO indoleamine 2, 3-dioxygenase -- ITM immunosuppressive microenvironment of tumor -- isoCA-4 isocombretastatin A-4 -- LbL layer-by-layer carrier system -- LCL long circulating liposome -- LDH layered double hydroxide -- MCM mobil composition of matter -- MDR multidrug resistance -- MDT magnetic drug targeting -- MSN mesoporous silica nanoparticle -- MUC mucin -- NPs nanoparticles -- PCL poly capro lactone -- PDL programmed cell death ligand -- PDT photodynamic therapy -- pDNA plasmid DNA -- PEG polyethylene glycol -- PLGA poly lactic-co-glycolic acid -- PNA peanut agglutinin -- PTT photothermal therapy -- QD quantum dots -- SERS surface enhanced Raman spectroscopy -- SLN solid lipid nanoparticle -- SQ squalene -- VEGF vascular endothelial growth factor
Colorectal cancer -- Chemotherapy -- Nanoparticle -- Imaging -- Drug delivery
Cancer -- Periodicals
Neoplasms -- Periodicals
Review Literature
Cancer -- Périodiques
Electronic journals
616.994 - Journal URLs:
- http://www.sciencedirect.com/science/journal/1044579X ↗
http://www.clinicalkey.com/dura/browse/journalIssue/1044579X ↗
http://www.clinicalkey.com.au/dura/browse/journalIssue/1044579X ↗
http://www.elsevier.com/journals ↗ - DOI:
- 10.1016/j.semcancer.2019.06.017 ↗
- Languages:
- English
- ISSNs:
- 1044-579X
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 8239.448340
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 15945.xml