Dietary flavonoids: Nano delivery and nanoparticles for cancer therapy. (February 2021)

• Record Type: Journal Article
• Authors: Aiello, Paola; Consalvi, Sara; Poce, Giovanna; Raguzzini, Anna; Toti, Elisabetta; Palmery, Maura; Biava, Mariangela; Bernardi, Marco; Kamal, Mohammad A.; Perry, George; Peluso, Ilaria
• Is Part Of: Seminars in cancer biology. Volume 69(2021)
• Page Start: 150
• Page End: 165
• Publication Date: 2021-02
• Subjects: 2-AAF 2-acetylaminofluorene -- 67LR laminin receptor 67 kDa -- ALP alkaline aminotransferate -- ALT alanine aminotransferate -- API apigenin -- AST aspartate aminotransferate -- ATC anthocyanin -- AUC area under the curve -- BaP Benzo[a]pyrene -- BCL baicalein -- BR biotin receptor -- BSA bovine serum albumin -- BW body weight -- CAT catalase -- CD44R CD44 receptor -- CH chitin -- CHOL cholesterol -- CIS cisplatin -- Cmax maximum plasma concentration -- CMS colloidal mesoporous silica -- COX-2 cyclooxygenase-2 -- CS chitosan -- CSU chondroitin sulfate -- CTX cyclophosphamide -- Cy cyanidin -- DEN diethyl nitrosamine -- DMBA 12-dimethyl(a)benz anthracene -- DOX doxorubicin -- Dp delphinidin -- DSPE-MPEG 1, 2-distearoyl-sn-glycero-3-phosphoethanolamine-N-methoxy(polyethylene glycol) -- EAC Ehrlich ascites carcinoma -- EGCG epigallocatechin-3-O-gallate -- EGFR epidermal growth factor receptor -- EIF5A2 oncogene eukaryotic translation initiation factor 5A2 -- ER estrogen receptor -- ERK extracellular signal-regulated kinase -- Eudragit aminoalkyl methacrylate copolymer E -- FA folic acid -- FITC fluorescein isothiocyanate -- FR folate receptors -- FU fucose -- GEN genistein -- GPNLC GeluPearl stabilized by Gelucire -- GPSLN GeluPearl with Precirol ATO 5 stabilized by Gelucire -- GSH glutatione -- GST glutatione-S-transferase -- HA hyaluronic acid -- Hb haemoglobin -- HES hesperetin -- IC50 half inibitory concentration -- IFN interferon -- IL interleukin -- IR integrin receptor -- KpK kaempferol -- MDA malondialdeide -- MDR multidrug resistance -- MNU N-methyl-Nitrosurea -- MPEG–PCL monomethoxy poly (ethylene glycol)–poly(ε-caprolactone) -- MPEG-PLA methoxy poly (ethylene glycol)-poly(lactide) -- M-PLGA–TPGS copolymer mannitol-functionalized Poly (lactic-co-glycolic acid) -- MPO myeloperoxidase -- MPP matrix metalloproteinases -- MSN mesoporous silica nanoparticles -- Mv malvidin -- NF-κB nuclear factor-κB -- NPs nanoparticles -- Nrf2 nuclear transcription factor-erythroid 2-related factor 2 -- PAA poly (acrylic acid) -- PBS phosphate buffered saline -- PC phosphatidylcholine -- PCL poly(ε-caprolactone) -- PCNA proliferating cell nuclear antigen -- Pe peonidin -- PE phosphatidylethanolamine -- PEG polyethylene glycol -- PEG-DSPE poly(ethylene glycol)–distearoylphosphatidylethanolamine -- PEG-PCL poly(ethylene glycol)-poly(-caprolactone) -- Pg pelargonidin -- PLA polylactic acid -- PLGA poly(lactic co-glycolic acid) -- PMSN arginine-glycine-aspartic acid peptide-MNS -- pPhe-pHis-PEG poly(phenylalanine)-b-poly(L-histidine) -b- poly(ethylene glycol) -- PS particle size -- PSA prostate specific antigen -- PSMA prostate-specific membrane antigen -- Pt petunidin -- PTX paclitaxel -- PVA poly-vinyl alcohol -- QCT quercetin -- ROS reactive oxygen species -- SA stearic acid -- SCID severe combined immunodeficient -- SNEDDS self-nano-emulsifying drug delivery system -- SOD superoxide dismutase -- SPC soybean phosphatidylcholine -- Tf transferrin -- TfR transferrin receptor -- Tmax time to reach peak concentration -- TMX tamoxifen -- TNF tumor necrosis factor -- TPGS d-α-tocopheryl polyethylene glycol 1000 succinate -- TPP triphenylphosphine -- TPs tea polyphenols -- TPT topotecan -- UVB ultraviolet-B -- VEGF vascular endothelial growth factor; Epigallocatechin gallate -- Quercetin -- Flavonoids -- Cancer -- Nanoparticle; Cancer -- Periodicals; Neoplasms -- Periodicals; Review Literature; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.semcancer.2019.08.029
• Languages: English
• ISSNs: 1044-579X

Abstract

Abstract: Application of nanotechnologies to cancer therapy might increase solubility and/or bioavailability of bioactive compounds of natural or synthetic origin and offers other potential benefits in cancer therapy, including selective targeting. In the present review we aim to evaluate in vivo studies on the anticancer activity of nanoparticles (NPs) obtained from food-derived flavonoids. From a systematic search a total of 60 studies were identified. Most of the studies involved the flavanol epigallocatechin-3-O-gallate and the flavonol quercetin, in both delivery and co-delivery (with anti-cancer drugs) systems. Moreover, some studies investigated the effects of other flavonoids, such as anthocyanins aglycones anthocyanidins, flavanones, flavones and isoflavonoids. NPs inhibited tumor growth in both xenograft and chemical-induced animal models of cancerogenesis. Encapsulation improved bioavailability and/or reduced toxicity of both flavonoids and/or co-delivered drugs, such as doxorubicin, docetaxel, paclitaxel, honokiol and vincristine. Moreover, flavonoids have been successfully applied in molecular targeted nanosystems. Selectivity for cancer cells involves pH- and/or reactive oxygen species-mediated mechanisms. Furthermore, flavonoids are good candidates as drug delivery for anticancer drugs in green synthesis systems. In conclusion, although human studies are needed, NPs obtained from food-derived flavonoids have promising anticancer effects in vivo .