Prebiotics in atopic dermatitis prevention and management. (March 2021)

• Record Type: Journal Article
• Authors: Lee, Ying Hui; Verma, Navin Kumar; Thanabalu, Thirumaran
• Is Part Of: Journal of functional foods. Volume 78(2021)
• Publication Date: 2021-03
• Subjects: Functional foods -- Gut microbiome -- Skin microbiome -- Cytokines; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2021.104352
• Languages: English
• ISSNs: 1756-4646

Abstract

Graphical abstract: Highlights: Imbalanced immune response is key driving factor in the progression of AD. Skin and the gut microbiome have an immense impact on AD pathophysiology. There is no cure for AD, and current therapeutic options have several limitations. Prebiotics favoring the growth of "good bacteria", can be used to treat AD. Abstract: Atopic dermatitis (AD) is a common, chronic inflammatory skin disease that is highly prevalent, especially among children. In addition to impaired skin barrier functions, AD is characterized by dysfunctional immunity and altered skin and gut microbiome. On the skin, there is an increased S. aureus colonization and reduced microbiome diversity while in the gut there is a diminution of short-chain fatty acid-producing bacteria, such as Bifidobacterium . There is no cure for AD, but symptoms can be managed by appropriate therapies aimed at minimizing exacerbations, and duration and degree of the AD flares. Functional foods, including probiotics and prebiotics, are being used to relieve AD symptoms. While probiotics supplement the gut with "good bacteria", prebiotics promote the growth of "good bacteria" on the skin and in the gut. Here, we review immune dysfunction and microbiome association in AD and potential use of prebiotics in the prevention and management of AD.