CNT and rGO reinforced PMMA based bone cement for fixation of load bearing implants: Mechanical property and biological response. (April 2021)

• Record Type: Journal Article
• Authors: Pahlevanzadeh, F.; Bakhsheshi-Rad, H.R.; Kharaziha, M.; Kasiri-Asgarani, M.; Omidi, M.; Razzaghi, M.; Ismail, Ahmad Fauzi; Sharif, Safian; RamaKrishna, Seeram; Berto, F.
• Is Part Of: Journal of the mechanical behavior of biomedical materials. Volume 116(2021)
• Publication Date: 2021-04
• Subjects: Polymethyl methacrylate -- Carbon nanotube -- Reduced graphene oxide -- Mechanical properties -- Biocompatibility; Biomedical materials -- Periodicals; Biomedical materials -- Mechanical properties -- Periodicals; Biomedical materials; Biomedical materials -- Mechanical properties; Periodicals; Electronic journals; 610.28
• DOI: 10.1016/j.jmbbm.2021.104320
• Languages: English
• ISSNs: 1751-6161

Abstract

Abstract: Polymethyl methacrylate (PMMA) bone cements (BCs) have some drawbacks, including limited bioactivity and bone formation, as well as inferior mechanical properties, which may result in failure of the BC. To deal with the mentioned issues, novel bioactive polymethyl methacrylate-hardystonite (PMMA-HT) bone cement (BC) reinforced with 0.25 and 0.5 wt% of carbon nanotube (CNT) and reduced graphene oxide (rGO) was synthesized. In this context, the obtained bone cements were evaluated in terms of their mechanical and biological characteristics. The rGO reinforced bone cement exhibited better mechanical properties to the extent that the addition of 0.5 wt% of rGO where its compressive and tensile strength of bioactive PMMA-HT/rGO cement escalated from 92.07 ± 0.72 MPa, and 40.02 ± 0.71 MPa to 187.48 ± 5.79 MPa and 64.92 ± 0.75 MPa, respectively. Besides, the mechanisms of toughening, apatite formation, and cell interaction in CNT and rGO encapsulated PMMA have been studied. Results showed that the existence of CNT and rGO in BCs led to increase of MG63 osteoblast viability, and proliferation. However, rGO reinforced bone cement was more successful in supporting MG63 cell attachment compared to the CNT counterpart due to its wrinkled surface, which made a suitable substrate for cell adhesion. Based on the results, PMMA-HT/rGO can be a proper bone cement for the fixation of load-bearing implants. Graphical abstract: Image 1 Highlights: Novel PMMA-based bone cement containing various amounts of rGO and CNT is prepared. Incorporation of rGO and CNT into PMMA-based cement increases its compressive, tensile and bending strength. Toughening and cell interactions mechanism of PMMA-based cement containing rGO and CNT is proposed.