Predictive Value of Hypoalbuminemia for Contrast-Associated Acute Kidney Injury: A Systematic Review and Meta-Analysis. (August 2021)

• Record Type: Journal Article
• Authors: Liu, Liwei; Lun, Zhubin; Wang, Bo; Lei, Li; Sun, Guoli; Liu, Jin; Guo, Zhaodong; He, Yibo; Song, Feier; Liu, Bowen; Chen, Guanzhong; Chen, Shiqun; Chen, Jiyan; Liu, Yong
• Is Part Of: Angiology. Volume 72:Number 7(2021)
• Page Start: 616
• Page End: 624
• Publication Date: 2021-08
• Subjects: hypoalbuminemia -- predictive value -- meta-analysis -- contrast-associated acute kidney injury; Blood-vessels -- Diseases -- Periodicals; Cardiovascular system -- Diseases -- Periodicals; 616.13005
• DOI: 10.1177/0003319721989185
• Languages: English
• ISSNs: 0003-3197

Abstract

Contrast-associated acute kidney injury (CA-AKI) is a major adverse complication of intravascular administration of contrast medium. Current studies have shown that hypoalbuminemia might be a novel risk factor of CA-AKI. This systematic review and meta-analysis was performed to evaluate the predictive value of hypoalbuminemia for CA-AKI. Relevant studies were identified in Ovid-Medline, PubMed, Embase, and Cochrane Library up to December 31, 2019. Two authors independently screened studies, consulting with a third author when necessary to resolve discrepancies. The pooled odds ratio (OR) was calculated to assess the association between hypoalbuminemia and CA-AKI using a random-effects model or fixed-effects model. Eight relevant studies involving a total of 18 687 patients met our inclusion criteria. The presence of hypoalbuminemia was associated with an increased risk of CA-AKI development (pooled OR: 2.59, 95% CI: 1.80-3.73). Hypoalbuminemia is independently associated with the occurrence of CA-AKI and may be a potentially modifiable factor for clinical intervention. This systematic review and meta-analysis was registered in PROSPERO (CRD42020168104).