Corrected: Correction: Long‐term follow‐up of low‐risk branchduct IPMNs of the pancreas: is main pancreatic duct dilatation the most worrisome feature?. Issue 6 (June 2018)

• Record Type: Journal Article
• Authors: Petrone, Maria Chiara; Magnoni, Pietro; Pergolini, Ilaria; Capurso, Gabriele; Traini, Mariaemilia; Doglioni, Claudio; Mariani, Alberto; Crippa, Stefano; Arcidiacono, Paolo Giorgio
• Is Part Of: Clinical and translational gastroenterology. Volume 9:Issue 6(2018)
• Publication Date: 2018-06
• Subjects: Stomach -- Diseases -- Periodicals; Intestines -- Diseases -- Periodicals; Gastroenterology; Gastrointestinal Diseases; Liver Diseases; Intestines -- Diseases; Stomach -- Diseases; Periodical; Periodicals; Fulltext; Internet Resources; Periodicals; Electronic journals; 616.33
• DOI: 10.1038/s41424-018-0026-3
• Languages: English
• ISSNs: 2155-384X

Abstract

Abstract : Objectives: : The management of branch‐duct IPMN remains controversial due to the relatively low rate of malignant degeneration and the uncertain predictive role of high‐risk stigmata (HRS) and worrisome features (WFs) identified by the 2012 International Consensus Guidelines. Our aim was to evaluate the evolution of originally lowrisk (Fukuoka‐negative) BD‐IPMNs during a long follow‐up period in order to determine whether the appearance of any clinical or morphological variables may be independently associated with the development of malignancy over time. Methods: : A prospectively collected database of all patients with BD‐IPMN referring to our Institute between 2002 and 2016 was retrospectively analyzed. Univariate and multivariate analysis of association between changes during follow‐up, including appearance of HRS/WFs, and development of malignancy (high‐grade dysplasia/invasive carcinoma) was performed. Results: : A total of 167 patients were selected for analysis, and seven developed malignant disease (4.2%). During a median follow‐up time of 55 months, HRS appeared in only three cases but predicted malignancy with 100% specificity. Worrisome features, on the other hand, appeared in 44 patients (26.3%). Appearance of mural nodules and MPD dilatation >5 mm showed a significant association with malignancy in multivariate analysis ( p = 0.004 and p = 0.001, respectively). MPD dilatation in particular proved to be the strongest independent risk factor for development of malignancy (OR = 24.5). Conclusions: : The risk of pancreatic malignancy in this population is low but definite. The presence of major WFs, and especially MPD dilatation, should prompt a tighter follow‐up with EUS and a valid cytological analysis whenever feasible.