A new paradigm for the regulation of the mammalian ribosomal RNA genes. (25th October 2006)

• Record Type: Journal Article
• Authors: Moss, T.; Stefanovsky, V.; Langlois, F.; Gagnon-Kugler, T.
• Is Part Of: Biochemical Society transactions. Volume 34:Number 6(2006)
• Page Start: 1079
• Page End: 1081
• Publication Date: 2006-10-25
• Subjects: growth factor -- mammalian cell -- ribosomal RNA gene -- RNA polymerase I -- rRNA -- transcription elongation; Biochemistry -- Congresses; 572
• DOI: 10.1042/BST0341079
• Languages: English
• ISSNs: 0300-5127

Abstract

Abstract : Ribosome assembly occurs co-transcriptionally on the rRNA genes. This process requires the co-ordinated expression and assembly of many hundreds of proteins and is finely tuned to cell and organism growth. Co-ordinate regulation of the rRNA genes and the ribosomal protein genes is therefore essential for high-fidelity ribosome assembly. Recent work shows that rRNA gene transcription is regulated at the level of elongation via the mitogen-activated protein kinase pathway. We argue that this may provide an explanation for the high fidelity of ribosome assembly.