Increased glycolysis in ageing cultured human diploid fibroblasts. Issue 9 (September 1984)

• Record Type: Journal Article
• Authors: Bittles, A. H.; Harper, N.
• Is Part Of: Bioscience reports. Volume 4:Issue 9(1984)
• Page Start: 751
• Page End: 756
• Publication Date: 1984-09
• Subjects: Molecular biology -- Periodicals; Cytology -- Periodicals; 572.8
• DOI: 10.1007/BF01128816
• Languages: English
• ISSNs: 0144-8463

Abstract

Abstract : With increasing population doubling in vitro, human diploid fibroblasts exhibited a highly significant increase in glucose uptake from the growth medium and a corresponding increase in lactate production. The switch to glycolysis occurred prior to the onset of changes in intracellular glucose and lactate concentrations or in the specific activity of the glycolytic regulatory enzyme, pyruvate kinase, it also preceded the morphological alterations held to be characteristic of cellular senescence.