NMR Studies of Drug Interaction with Membranes and Membrane-Associated Proteins. Issue 2 (April 2002)

• Record Type: Journal Article
• Authors: Xu, Yan; Yushmanov, Victor E.; Tang, Pei
• Is Part Of: Bioscience reports. Volume 22:Issue 2(2002)
• Page Start: 175
• Page End: 196
• Publication Date: 2002-04
• Subjects: Model membrane -- membrane protein -- ion channel -- gramicidin -- anesthetic -- nuclear magnetic resonance -- NMR -- nuclear overhauser effect; Molecular biology -- Periodicals; Cytology -- Periodicals; 572.8
• DOI: 10.1023/A:1020182404940
• Languages: English
• ISSNs: 0144-8463

Abstract

Abstract : This review focuses on the recent developments in the study of drug interactions with biological membranes and membrane-associated proteins using nuclear magnetic resonance (NMR) spectroscopy and other spectroscopic techniques. Emphasis is placed on a class of low-affinity neurological agents as exemplified by volatile general anesthetics and structurally related compounds. The technical aspects are reviewed of how to prepare membrane-mimetic systems and of NMR approaches that are either in current use or opening new prospects. A brief literature survey covers studies ranging from drug distribution in simplified lipid matrix to specific drug interaction with neuronal receptors reconstituted in complicated synthetic membrane systems.