Stretch activated ion channels in ventricular myocytes. Issue 5 (October 1988)

• Record Type: Journal Article
• Authors: Craelius, William; Chen, Victor; El-Sherif, Nabil
• Is Part Of: Bioscience reports. Volume 8:Issue 5(1988)
• Page Start: 407
• Page End: 414
• Publication Date: 1988-10
• Subjects: channels -- ventricle -- myocyte -- voltage clamp -- stretch receptor; Molecular biology -- Periodicals; Cytology -- Periodicals; 572.8
• DOI: 10.1007/BF01121637
• Languages: English
• ISSNs: 0144-8463

Abstract

Abstract : Patch-clamp recordings from ventricular myocytes of neonatal rats identified ionic channels that open in response to membrane stretch caused by negative pressures (1 to 6 cm Hg) in the electrode. The stretch response, consisting of markedly increased channel opening frequency, was maintained, with some variability, during long (>40 seconds) stretch applications. The channels have a conductance averaging 120 pS in isotonic KCl, have a mean reversal potential 31 mV depolarized from resting membrane potential, and do not require external Ca ++ for activation. The channels appear to be relatively non-selective for cations. Since they are gated by physiological levels of tension, stretch-activated channels may represent, a cellular control system wherein beat-to-beat tension and/or osmotic balance modulate a portion of membrane conductance.