Structure of a gap junction gene: Rat connexin-32. Issue 5 (October 1988)

• Record Type: Journal Article
• Authors: Miller, Todd; Dahl, Gerhard; Werner, Rudolf
• Is Part Of: Bioscience reports. Volume 8:Issue 5(1988)
• Page Start: 455
• Page End: 464
• Publication Date: 1988-10
• Subjects: connexin -- gap junction -- gene structure; Molecular biology -- Periodicals; Cytology -- Periodicals; 572.8
• DOI: 10.1007/BF01121644
• Languages: English
• ISSNs: 0144-8463

Abstract

Abstract : A genomic clone for the rat liver gap junction protein (connexin-32) was isolated and characterized by restriction enzyme mapping and sequence analysis. While the complete coding sequence is contained within one uninterrupted block, the 5′-untranslated region of the transcript contains a 6.1 kb intron. Both S1 nuclease protection and primer extension assays indicate multiple transcription start sites. Sequences homologous to cAMP response elements are found near the transcription start sites and within the 3′-end of the intron.