VEGF receptor trafficking in angiogenesis. (19th November 2009)

• Record Type: Journal Article
• Authors: Scott, Alice; Mellor, Harry
• Is Part Of: Biochemical Society transactions. Volume 37:Number 6(2009)
• Page Start: 1184
• Page End: 1188
• Publication Date: 2009-11-19
• Subjects: angiogenesis -- endocytosis -- intracellular trafficking -- vascular endothelial growth factor (VEGF); Biochemistry -- Congresses; 572
• DOI: 10.1042/BST0371184
• Languages: English
• ISSNs: 0300-5127

Abstract

Abstract : The intracellular trafficking of receptors provides a way to control the overall sensitivity of a cell to receptor stimulation. These sorting pathways are also used to shape the balance of signals that are generated in response to receptor activation. The major pro-angiogenic growth factor receptor is VEGFR2 (vascular endothelial growth factor 2). VEGFR2 activates a very similar set of signalling pathways to other RTKs (receptor tyrosine kinases); however, its intracellular trafficking is very different. Furthermore, VEGFR2 can form a complex with a range of different angiogenic regulators that in turn regulate the trafficking of VEGFR2 through the endosomal pathway. This regulated trafficking of VEGFR2 has important consequences for angiogenic signalling and is a clear demonstration of how the endosomal pathway plays a critical role in connecting receptor signalling pathways to cellular events.