Nyctohemeral rhythmicity of type II thyroxine 5′-deiodinase activity in the pineal gland but not in the Harderian gland of the Swiss mouse. Issue 2 (April 1991)

• Record Type: Journal Article
• Authors: Rubio, A.; Osuna, C.; Lopez-Gonzalez, M. A.; Reiter, R. J.; Guerrero, J. M.
• Is Part Of: Bioscience reports. Volume 11:Issue 2(1991)
• Page Start: 111
• Page End: 117
• Publication Date: 1991-04
• Subjects: deiodinase -- thyroxine -- Swiss mouse -- pineal -- Harderian; Molecular biology -- Periodicals; Cytology -- Periodicals; 572.8
• DOI: 10.1007/BF01119198
• Languages: English
• ISSNs: 0144-8463

Abstract

Abstract : Type II thyroxine 5′-deiodinase (5′-D) activity in both pineal and Harderian glands of the Swiss mouse was studied. Pineal 5′-D activity exhibited a nyctohemeral profile with a maximal peak value at 05.00 h, which coincides with that for pineal melatonin production. However, no rhythm of 5′-D activity in the Harderian gland could be found. In pineal gland, light at night inhibited the nocturnal increase in 5′-D activity, while isoproterenol, a β-adrenergic agonist, could not stimulate the enzyme. In the Harderian gland, neither darkness, nor light at night, or isoproterenol were capable of modifying basal values of 5′-D activity.