Increased Use of Medications for Erectile Dysfunction in Men With Ulcerative Colitis and Crohn's Disease Compared to Men Without Inflammatory Bowel disease: A Nationwide cohort Study. (September 2018)

• Record Type: Journal Article
• Authors: Friedman, S; Magnussen, B; O'Toole, A; Fedder, J; Larsen, M D; Nørgård, B M
• Is Part Of: American journal of gastroenterology. Volume 113:Number 9(2018)
• Publication Date: 2018-09
• Subjects: Stomach -- Diseases -- Periodicals; Intestines -- Diseases -- Periodicals; Gastroenterology -- Periodicals; Gastrointestinal Diseases -- Periodicals; Electronic journals; Periodicals; 616.33
• DOI: 10.1038/s41395-018-0177-6
• Languages: English
• ISSNs: 0002-9270

Abstract

Abstract : BACKGROUND: Men with inflammatory bowel disease (IBD) may have decreased sexual function due to factors related to the underlying disease, medication, and/or surgery. We aimed to examine the use of erectile dysfunction (ED) medications in men with IBD. METHODS: This is a nationwide cohort study based on the Danish registries, comprising all men >18 years old with IBD during 1 January 1995 through December 2016. The cohorts included 31, 498 men with IBD and 314, 980 age‐matched men without IBD. Our main outcome was a first prescription of an ED medication. Cox regression analyses were used to estimate the hazard rate (HR) for use of ED medications, controlled for multiple time‐varying covariates. RESULTS: Overall, 21, 966 (69.7%) men had ulcerative colitis (UC) while 9532 (30.3%) had Crohn's disease (CD). Men with a first ED prescription numbered 3749 (11.9%) (men with IBD) and 30, 635 (9.7%) (men without IBD). Adjusting for central nervous system and intestinal anti‐inflammatory medications, systemic corticosteroids and co‐morbidities, the HR was 1.19 (95% CI: 1.13–1.26) (IBD and no prior IBD operation), and 1.31 (95% CI: 1.20–1.43) (IBD and prior IBD operation). The adjusted HR for UC was 1.17 (95% CI: 1.10–1.24) (no operation) and 1.43 (95% CI: 1.27–1.61) (prior operation), and for CD 1.26 (95% CI: 1.15–1.38) (no operation) and 1.20 (95% CI: 1.06–1.35) (prior operation). DISCUSSION: Men with IBD are more likely to fill an ED prescription than men without IBD. This result is significant regardless of a history of IBD surgery.