Cellular geography of IP3 receptors, STIM and Orai: a lesson from secretory epithelial cells. (19th January 2012)

• Record Type: Journal Article
• Authors: Dingsdale, Hayley; Voronina, Svetlana; Haynes, Lee; Tepikin, Alexei; Lur, Gyorgy
• Is Part Of: Biochemical Society transactions. Volume 40:Number 1(2012)
• Page Start: 108
• Page End: 111
• Publication Date: 2012-01-19
• Subjects: calcium signalling -- inositol 1, 4, 5-trisphosphate receptor -- Orai1 -- pancreatic acinar cell -- store-operated calcium entry (SOCE) -- stromal interaction molecule 1 (STIM1); Biochemistry -- Congresses; 572
• DOI: 10.1042/BST20110639
• Languages: English
• ISSNs: 0300-5127

Abstract

Abstract : Pancreatic acinar cells exhibit a remarkable polarization of Ca 2+ release and Ca 2+ influx mechanisms. In the present brief review, we discuss the localization of channels responsible for Ca 2+ release [mainly IP3 (inositol 1, 4, 5-trisphosphate) receptors] and proteins responsible for SOCE (store-operated Ca 2+ entry). We also place these Ca 2+ -transporting mechanisms on the map of cellular organelles in pancreatic acinar cells, and discuss the physiological implications of the cellular geography of Ca 2+ signalling. Finally, we highlight some unresolved questions stemming from recent observations of co-localization and co-immunoprecipitation of IP3 receptors with Orai channels in the apical (secretory) region of pancreatic acinar cells.