Role of AMP-activated protein kinase in the regulation of gene transcription. (April 2002)

• Record Type: Journal Article
• Authors: Leclerc, I.; Viollet, B.; da Silva Xavier, G.; Kahn, A.; Rutter, G. A.
• Is Part Of: Biochemical Society transactions. Volume 30:Number 2(2002)
• Page Start: 307
• Page End: 311
• Publication Date: 2002-04
• Subjects: ACC, acetyl-CoA carboxylase -- Ad.αIDN, adenovirus encoding a dominant negative form of the α I-subunit of AMPK -- AICAR, 5-aminoimidazole-4-carboxamide riboside -- AMPK, AMP-activated protein kinase -- FAS, fatty acid synthase -- GK, glucokinase -- GLUT, glucose transporter -- G6P, glucose 6-phosphate -- HMG-CoA, 3-hydroxy-3-methyl-glutaryl-coenzyme A -- HNF, hepatocyte nuclear factor -- L-PK, L-type pyruvate kinase -- PEPCK, phosphoenolpyruvate carboxykinase -- PPI, preproinsulin -- SNF1, sucrose non-fermenting-1 complex -- SREBPIc, sterol response element binding protein Ic; gene expression -- glucose -- pancreatic β-cell; Biochemistry -- Congresses; 572
• DOI: 10.1042/bst0300307
• Languages: English
• ISSNs: 0300-5127

Abstract

Abstract : AMP-activated protein kinase (AMPK) is a regulator of cellular metabolism in response to changes in the energy status of the cells. AMPK was known to shut down energy-consuming pathways in response to a fall in the ATP/AMP ratio by phosphorylating key enzymes of intermediate metabolism. Here we will discuss the recent evidence implicating AMPK in the regulation of gene expression in mammals, mainly in the liver and in the pancreatic β-cells.