Thiol redox control via thioredoxin and glutaredoxin systems. (26th October 2005)

• Record Type: Journal Article
• Authors: Holmgren, A.; Johansson, C.; Berndt, C.; Lönn, M.E.; Hudemann, C.; Lillig, C.H.
• Is Part Of: Biochemical Society transactions. Volume 33:Number 6(2005)
• Page Start: 1375
• Page End: 1377
• Publication Date: 2005-10-26
• Subjects: disulphide -- glutaredoxin (Grx) -- GSH -- thiol redox control -- thioredoxin (Trx) -- thioredoxin reductase (TrxR); Biochemistry -- Congresses; 572
• DOI: 10.1042/BST0331375
• Languages: English
• ISSNs: 0300-5127

Abstract

Abstract : The Trx (thioredoxin) and Grx (glutaredoxin) systems control cellular redox potential, keeping a reducing thiol-rich intracellular state, which on generation of reactive oxygen species signals through thiol redox control mechanisms. Here, we give a brief overview of the human Trx and Grx systems. The main part focuses on our current knowledge about mitochondrial Grx2, which facilitates mitochondrial redox homoeostasis during oxidative stress-induced apoptosis.