Regulation of small GTP-binding proteins by insulin. (20th March 2006)

• Record Type: Journal Article
• Authors: Welsh, G.I.; Hers, I.; Wherlock, M.; Tavaré, J.M.
• Is Part Of: Biochemical Society transactions. Volume 34:Number 2(2006)
• Page Start: 209
• Page End: 212
• Publication Date: 2006-03-20
• Subjects: AS160 -- glucose homoeostasis -- GTPase -- insulin -- protein kinase B (PKB) -- Rab; Biochemistry -- Congresses; 572
• DOI: 10.1042/BST0340209
• Languages: English
• ISSNs: 0300-5127

Abstract

Abstract : Several members of the extensive family of small GTP-binding proteins are regulated by insulin, and have been implicated in insulin action on glucose uptake. These proteins are themselves negatively regulated by a series of specific GAPs (GTPase-activating proteins). Interestingly, there is increasing evidence to suggest that PKB (protein kinase B)-dependent phosphorylation of some GAPs may relieve this negative regulation and so lead to the activation of the target small GTP-binding protein. We review recent evidence that this may be the case, and place specific emphasis on the role of these pathways in insulin-stimulated glucose uptake.