Nitric oxide, hypoxia and brain inflammation. (26th October 2004)

• Record Type: Journal Article
• Authors: Mander, P.; Brown, G.C.
• Is Part Of: Biochemical Society transactions. Volume 32:Number 6(2004)
• Page Start: 1068
• Page End: 1069
• Publication Date: 2004-10-26
• Subjects: cytochrome oxidase -- glia -- glutamate -- hypoxia -- inducible nitric oxide synthase (iNOS); Biochemistry -- Congresses; 572
• DOI: 10.1042/BST0321068
• Languages: English
• ISSNs: 0300-5127

Abstract

Abstract : NO (nitric oxide) acutely and potently inhibits mitochondrial cytochrome oxidase in competition with oxygen, thereby raising the apparent K M for oxygen of mitochondria and neurons into the physiological or pathological range. We find that NO from an NO donor or glial inducible NOS (nitric oxide synthase) highly sensitizes neurons to hypoxia-induced death, probably via the NO–oxygen competition at cytochrome oxidase. Thus the NO from neuronal NOS during excitotoxicity or the NO from inducible NOS during inflammation may sensitize the brain to hypoxic/ischaemic damage.