Ran control of mitosis in human cells: gradients and local signals. (24th November 2010)

• Record Type: Journal Article
• Authors: Roscioli, Emanuele; Bolognesi, Alessio; Guarguaglini, Giulia; Lavia, Patrizia
• Is Part Of: Biochemical Society transactions. Volume 38:Number 6(2010)
• Page Start: 1709
• Page End: 1714
• Publication Date: 2010-11-24
• Subjects: inportin β -- mitosis -- Ran GTPase -- spindle microtubule; Biochemistry -- Congresses; 572
• DOI: 10.1042/BST0381709
• Languages: English
• ISSNs: 0300-5127

Abstract

Abstract : Roles of the GTPase Ran in cell life and division rely on a largely conserved mechanism, i.e. Ran's ability to interact with transport vectors. Modes of control of downstream factors, however, are diversified at particular times of the cell cycle. Specificity and fine-tuning emerge most clearly during mitosis. In the present article, we focus on the distinction between global mitotic control by the chromosomal Ran gradient and specific spatial and temporal control operated by localized Ran network members at sites of the mitotic apparatus in human cells.