Emerging role of Alzheimer's disease-associated ubiquilin-1 in protein aggregation. (19th January 2010)

• Record Type: Journal Article
• Authors: Haapasalo, Annakaisa; Viswanathan, Jayashree; Bertram, Lars; Soininen, Hilkka; Tanzi, Rudolph E.; Hiltunen, Mikko
• Is Part Of: Biochemical Society transactions. Volume 38:Number 1(2010)
• Page Start: 150
• Page End: 155
• Publication Date: 2010-01-19
• Subjects: aggresome -- Alzheimer's disease (AD) -- presenilin -- proteasome -- protein aggregation -- ubiquilin-1; Biochemistry -- Congresses; 572
• DOI: 10.1042/BST0380150
• Languages: English
• ISSNs: 0300-5127

Abstract

Abstract : Abnormal protein aggregation and intracellular or extracellular accumulation of misfolded and aggregated proteins are key events in the pathogenesis of different neurodegenerative diseases. Furthermore, endoplasmic reticulum stress and impairment of the ubiquitin–proteasome system probably contribute to neurodegeneration in these diseases. A characteristic feature of AD (Alzheimer's disease) is the abnormal accumulation of Aβ (amyloid β-peptide) in the brain. Evidence shows that the AD-associated PS (presenilin) also forms aggregates under certain conditions and that another AD-associated protein, ubiquilin-1, controls protein aggregation and deposition of aggregated proteins. Here, we review the current knowledge of ubiquilin-1 and PS in protein aggregation and related events that potentially influence neurodegeneration.