Superoxide, peroxynitrite and oxidative/nitrative stress in inflammation. (25th October 2006)

• Record Type: Journal Article
• Authors: Salvemini, D.; Doyle, T.M.; Cuzzocrea, S.
• Is Part Of: Biochemical Society transactions. Volume 34:Number 5(2006)
• Page Start: 965
• Page End: 970
• Publication Date: 2006-10-25
• Subjects: inflammation -- pain -- peroxynitrite -- reactive oxygen species -- superoxide -- tyrosine nitration; Biochemistry -- Congresses; 572
• DOI: 10.1042/BST0340965
• Languages: English
• ISSNs: 0300-5127

Abstract

Abstract : A considerable body of evidence suggests that formation of potent reactive oxygen species and resulting oxidative/nitrative stress play a major role in acute and chronic inflammation and pain. Much of the knowledge in this field has been gathered by the use of pharmacological and genetic approaches. In this mini review, we will evaluate recent advances made towards understanding the roles of reactive oxygen species in inflammation, focusing in particular on superoxide and peroxynitrite. Given the limited space to cover this broad topic, here we will refer the reader to comprehensive review articles whenever possible.