The role of ESCRT proteins in attenuation of cell signalling. (20th January 2009)
- Record Type:
- Journal Article
- Title:
- The role of ESCRT proteins in attenuation of cell signalling. (20th January 2009)
- Main Title:
- The role of ESCRT proteins in attenuation of cell signalling
- Authors:
- Rodahl, Lina M.
Stuffers, Susanne
Lobert, Viola H.
Stenmark, Harald - Abstract:
- Abstract : The ESCRT (endosomal sorting complex required for transport) machinery consists of four protein complexes that mediate sorting of ubiquitinated membrane proteins into the intraluminal vesicles of multivesicular endosomes, thereby targeting them for degradation in lysosomes. In the present paper, we review how ESCRT-mediated receptor down-regulation affects signalling downstream of Notch and growth factor receptors, and how ESCRTs may control cell proliferation, survival and cytoskeletal functions and contribute to tumour suppression.
- Is Part Of:
- Biochemical Society transactions. Volume 37:Number 1(2009)
- Journal:
- Biochemical Society transactions
- Issue:
- Volume 37:Number 1(2009)
- Issue Display:
- Volume 37, Issue 1 (2009)
- Year:
- 2009
- Volume:
- 37
- Issue:
- 1
- Issue Sort Value:
- 2009-0037-0001-0000
- Page Start:
- 137
- Page End:
- 142
- Publication Date:
- 2009-01-20
- Subjects:
- apoptosis -- endosomal sorting complex required for transport (ESCRT) -- growth factor receptor -- Notch -- tumour suppressor -- ubiquitin
Biochemistry -- Congresses
572 - Journal URLs:
- https://portlandpress.com/biochemsoctrans ↗
- DOI:
- 10.1042/BST0370137 ↗
- Languages:
- English
- ISSNs:
- 0300-5127
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library HMNTS - ELD Digital store
- Ingest File:
- 15894.xml