Pleiotropy of microRNA-192 in the kidney. (20th July 2012)

• Record Type: Journal Article
• Authors: Jenkins, Robert H.; Martin, John; Phillips, Aled O.; Bowen, Timothy; Fraser, Donald J.
• Is Part Of: Biochemical Society transactions. Volume 40:Number 4(2012)
• Page Start: 762
• Page End: 767
• Publication Date: 2012-07-20
• Subjects: hepatocyte nuclear factor (HNF) -- microRNA (miRNA) -- p53 -- renal fibrosis -- transcription; Biochemistry -- Congresses; 572
• DOI: 10.1042/BST20120085
• Languages: English
• ISSNs: 0300-5127

Abstract

Abstract : Diverse aetiologies result in significant deviation from homoeostasis in the kidney, leading to CKD (chronic kidney disease). CKD progresses to end-stage renal disease principally as a result of renal fibrosis, although the molecular mechanisms underlying this fibrotic process are still poorly understood. miRNAs (microRNAs) are a recently discovered family of endogenous short single-stranded RNAs that regulate global gene expression at the post-transcriptional level. The recent findings from our laboratory and others discussed in the present review outline pleiotropic roles for miR - 192 in renal homoeostasis and in the fibrotic kidney. We describe miR - 192 -driven anti-and pro-fibrotic effects via the repression of ZEB1 and ZEB2 (zinc finger E-box-binding homeobox proteins 1 and 2), resulting in changes in extracellular matrix deposition and cell differentiation.