Compartmentalized cAMP signalling is important in the regulation of Ca2+ cycling in the heart. (21st July 2006)

• Record Type: Journal Article
• Authors: Lygren, B.; Taskén, K.
• Is Part Of: Biochemical Society transactions. Volume 34:Number 4(2006)
• Page Start: 489
• Page End: 491
• Publication Date: 2006-07-21
• Subjects: A-kinase-anchoring protein (AKAP) -- cAMP -- excitation–contraction coupling -- heart -- phospholamban (PLB) -- protein kinase A (PKA) -- sarcoplasmic/endoplasmic-reticulum Ca2+-ATPase 2 (SERCA2); Biochemistry -- Congresses; 572
• DOI: 10.1042/BST0340489
• Languages: English
• ISSNs: 0300-5127

Abstract

Abstract : Co-ordinated myocyte handling of calcium is essential for efficient excitation–contraction coupling in the heart. The calcium cycling activity can be modulated by adrenergic stimulation and subsequent phosphorylation. Important functional consequences of phosphorylation include a greater influx of calcium through the voltage-dependent L-type Ca 2+ channel and a greater release of calcium from SR (sarcoplasmic reticulum) through the ryanodine R2 receptor. Furthermore, a more efficient reuptake through SERCA2 (sarcoplasmic/endoplasmic-reticulum Ca 2+ -ATPase 2) is a result of phosphorylation of its regulatory protein phospholamban. Compartmentalized signalling is important in this signalling cascade, and A-kinase-anchoring proteins play a central role by providing a high level of specificity.