Applications of nanopipettes in bionanotechnology. (22nd July 2009)

• Record Type: Journal Article
• Authors: Ying, Liming
• Is Part Of: Biochemical Society transactions. Volume 37:Number 4(2009)
• Page Start: 702
• Page End: 706
• Publication Date: 2009-07-22
• Subjects: controlled delivery -- nanomanipulation -- nanopipette -- nanosensor -- scanning-ion conductance microscopy (SICM) -- single molecule; Biochemistry -- Congresses; 572
• DOI: 10.1042/BST0370702
• Languages: English
• ISSNs: 0300-5127

Abstract

Abstract : At present, technical hurdles remain in probing biochemical processes in living cells and organisms at nanometre spatial resolution, millisecond time resolution and with high specificity and single-molecule sensitivity. Owing to its unique shape, size and electrical properties, the nanopipette has been used to obtain high-resolution topographic images of live cells under physiological conditions, and to create nanoscale features by controlled delivery of biomolecules. In the present paper, I discuss recent progress in the development of a family of new methods for nanosensing and nanomanipulation using nanopipettes.