Lipid homoeostasis and Golgi secretory function. (22nd May 2006)

• Record Type: Journal Article
• Authors: Lev, S.
• Is Part Of: Biochemical Society transactions. Volume 34:Number 3(2006)
• Page Start: 363
• Page End: 366
• Publication Date: 2006-05-22
• Subjects: diacylglycerol -- lipid homoeostasis -- Nir2 -- phosphatidic acid -- phosphatidylinositol -- trans-Golgi network; Biochemistry -- Congresses; 572
• DOI: 10.1042/BST0340363
• Languages: English
• ISSNs: 0300-5127

Abstract

Abstract : The unique lipid composition of the Golgi membranes is critical for maintaining their structural and functional identity, and is regulated by local lipid metabolism, a variety of lipid-binding, -modifying, -sensing and -transfer proteins, and by selective lipid sorting mechanisms. A growing body of evidence suggests that certain lipids, such as phosphoinositides and diacylglycerol, regulate Golgi-mediated transport events. However, their exact role in this process, and the underlying mechanisms that maintain their critical levels in specific membrane domains of the Golgi apparatus, remain poorly understood. Nevertheless, recent advances have revealed key regulators of lipid homoeostasis in the Golgi complex and have demonstrated their role in Golgi secretory function.