Vascular matrix adhesion and the blood–brain barrier. (25th October 2006)

• Record Type: Journal Article
• Authors: del Zoppo, G.J.; Milner, R.; Mabuchi, T.; Hung, S.; Wang, X.; Koziol, J.A.
• Is Part Of: Biochemical Society transactions. Volume 34:Number 6(2006)
• Page Start: 1261
• Page End: 1266
• Publication Date: 2006-10-25
• Subjects: blood–brain barrier -- dystroglycan -- extracellular matrix -- focal ischaemia -- integrin -- matrix adhesion receptor; Biochemistry -- Congresses; 572
• DOI: 10.1042/BST0341261
• Languages: English
• ISSNs: 0300-5127

Abstract

Abstract : The integrity of the cerebral microvasculature depends on the interaction between its component cells and the extracellular matrix, as well as reorganized cell–cell interactions. In the central nervous system, matrix adhesion receptors are expressed in the microvasculature and by neurons and their supporting glial cells. Cells within cerebral microvessels express both the integrin and dystroglycan families of matrix adhesion receptors. However, the functional significance of these receptors is only now being explored. Endothelial cells and astrocytes within cerebral capillaries co-operate to generate and maintain the basal lamina and the unique barrier functions of the endothelium. Integrins and the dystroglycan complex are found on the matrix-proximate faces of both endothelial cells and astrocyte end-feet. Pericytes rest against the basal lamina. In the extravascular compartment, select integrins are expressed on neurons, microglial cells and oligodendroglia. Significant alterations in both cellular adhesion receptors and their matrix ligands occur during focal cerebral ischaemia, which support their functional significance in the normal state. We propose that matrix adhesion receptors are essential for the maintenance of the integrity of the blood–brain permeability barrier and that modulation of these receptors contributes to alterations in the barrier during brain injury.