B-lymphocyte depletion therapy in rheumatoid arthritis and other autoimmune disorders. (August 2002)

• Record Type: Journal Article
• Authors: Edwards, J. C. W.; Leandro, M.J.; Cambridge, G.
• Is Part Of: Biochemical Society transactions. Volume 30:Number 4(2002)
• Page Start: 824
• Page End: 828
• Publication Date: 2002-08
• Subjects: CD20 -- rituximab -- systemic lupus erythematosus; ITP, immune thrombocytopenic purpura -- RA, rheumatoid arthritis -- SLE, systemic lupus erythematosus -- FcγR, Fcγ receptor; Biochemistry -- Congresses; 572
• DOI: 10.1042/bst0300824
• Languages: English
• ISSNs: 0300-5127

Abstract

Abstract : B-lymphocyte depletion therapy is being explored in a wide range of autoimmune disorders. In many, there is early evidence for efficacy, and immunosuppression has not been a major problem. The mechanism of action is unclear, but appears to be consistent with the lowering of autoantibody levels, where relevant antibodies are quantifiable. An interesting finding is the persistence of clinical improvement for periods of 1 year or more after B-lymphocyte return, which supports the concept that stochastic generation of rare pathogenic B-lymphocyte subsets may be a rate-limiting step in pathogenesis.