Assessment of risk factors for postoperative cognitive dysfunction after coronary artery bypass surgery: a single-center retrospective cohort study. Issue 2 (26th February 2021)

• Record Type: Journal Article
• Authors: Sun, Yongtao; Feng, Hai; Zou, Ting; Hou, Ming; Jin, Yanwu; Gu, Changping; Wang, Yuelan; Li, Juan; Liu, Mengjie; Zhang, Min; Gao, Yalei
• Is Part Of: Bioscience reports. Volume 41:Issue 2(2021)
• Publication Date: 2021-02-26
• Subjects: Coronary artery bypass grafting -- Neuropsychological test -- Postoperative cognitive dysfunction -- Risk factors; Molecular biology -- Periodicals; Cytology -- Periodicals; 572.8
• DOI: 10.1042/BSR20190719
• Languages: English
• ISSNs: 0144-8463

Abstract

Abstract: Aim: To find out risk factors for postoperative cognitive dysfunction (POCD) after coronary artery bypass grafting (CABG), and to provide basis for clinical prevention of POCD. A total of 88 patients who underwent CABG were surveyed with Telephone Questionnaire (TICS-M) for their cognitive impairment after 3, 7, 21, 90, 180 days post-surgery. The occurrence of POCD was diagnosed by Neuropsychological Battery which included Vocabular Learning Test (VLT), Wisconsin Card Sorting Test (WCST), Trail Making Test (TMT) and Symbol Digit Modalities Test (SDMT). The preoperative, intraoperative and postoperative risk factors were assessed by the χ 2 or t test. Multivariate analysis was used to study the correlation between the risk factors and the occurrence of POCD. Age, aortic plaque, carotid artery stenosis, cerebrovascular disease, anesthesia time, the rate of decline in intraoperative hemoglobin concentration (ΔHb) and systemic inflammatory response syndrome (SIRS) score on postoperative day 2 had statistically significant ( P <0.05) influence on the occurrence of POCD. Aortic plaque, carotid artery stenosis, anesthesia time and SIRS score (odds ratio (OR) value > 1, P <0.05) are the risk factors for POCD. The incidence of day-21 and -180 POCD was approximately 26.1 and 22.7%, respectively.