Correlations between glycolysis with clinical traits and immune function in bladder urothelial carcinoma. Issue 2 (26th February 2021)

• Record Type: Journal Article
• Authors: Che, Kai; Han, Wenkai; Li, Danxia; Cui, Shuxia; Zhang, Mingxin; Yang, Xiaokun; Niu, Haitao
• Is Part Of: Bioscience reports. Volume 41:Issue 2(2021)
• Publication Date: 2021-02-26
• Subjects: bladder urothelial carcinoma -- clinical characteristics -- glycolysis -- immune activity; Molecular biology -- Periodicals; Cytology -- Periodicals; 572.8
• DOI: 10.1042/BSR20203982
• Languages: English
• ISSNs: 0144-8463

Abstract

Abstract: Background: Glycolysis was a representative hallmark in the tumor microenvironment (TME), and we aimed to explore the correlations between glycolysis with immune activity and clinical traits in bladder urothelial carcinoma (BLCA). Methods: Our study obtained glycolysis scores for each BLCA samples from TCGA by a single-sample gene set enrichment analysis (ssGSEA) algorithm, based on a glycolytic gene set. The relationship between glycolysis with prognosis, clinical characteristics, and immune function were investigated subsequently. Results: We found that enhanced glycolysis was associated with poor prognosis and metastasis in BLCA. Moreover, glycolysis had a close correlation with immune function, and enhanced glycolysis increased immune activities. In other words, glycolysis had a positive correlation with immune activities. Immune checkpoints such as IDO1, CD274, were up-regulated in high-glycolysis group as well. Conclusion: We speculated that in BLCA, elevated glycolysis enhanced immune function, which caused tumor cells to overexpress immune checkpoints to evade immune surveillance. Inhibition of glycolysis might be a promising assistant for immunotherapy in bladder cancer.