Suppression of beta 2 adrenergic receptor actions prevent UVB mediated cutaneous squamous cell tumorigenesis through inhibition of VEGF‐A induced angiogenesis. Issue 3 (22nd January 2021)

• Record Type: Journal Article
• Authors: Lu, Kai; Bhat, Madhavi; Peters, Sara; Mitra, Rita; Oberyszyn, Tatiana; Basu, Sujit
• Is Part Of: Molecular carcinogenesis. Volume 60:Issue 3(2021)
• Page Start: 172
• Page End: 178
• Publication Date: 2021-01-22
• Subjects: beta 2 adrenergic receptor blockers -- skin -- tumorigenesis -- UVB; Carcinogenesis -- Molecular aspects -- Periodicals; 616.994071
• DOI: 10.1002/mc.23281
• Languages: English
• ISSNs: 0899-1987

Abstract

Abstract: Although beta 2 adrenergic receptors (β2 ADR) are present in the keratinocytes, their role in cutaneous squamous cell tumorigenesis needs to be ascertained. For the first time, we report here that selective β2 ADR antagonists by inhibiting β2 ADR actions significantly retarded the progression of ultraviolet B (UVB) induced premalignant cutaneous squamous cell lesions. These antagonists acted by inhibiting vascular endothelial growth factor‐A (VEGF) mediated angiogenesis to prevent UVB radiation‐induced squamous cell carcinoma of the skin.