A new Tetrahydrofuran sesquiterpene skeleton from Artemisia sieberi. Issue 2 (6th October 2020)

• Record Type: Journal Article
• Authors: Mohamed, Tarik A.; Albadry, Hazem A.; Elshamy, Abdelsamed I.; Younes, Sabry H. H.; Shahat, Abdelaaty A.; El‐wassimy, Mohamed T.; Moustafa, Mahmoud F.; Hegazy, Mohamed‐Elamir F.
• Is Part Of: Journal of the Chinese Chemical Society. Volume 68:Issue 2(2021)
• Page Start: 338
• Page End: 342
• Publication Date: 2020-10-06
• Subjects: Artemisia sieberi -- cancer cells -- cytotoxic assay -- Tetrahydrofuran sesquiterpene; Chemistry -- Periodicals; Electronic journals; 540.5
• DOI: 10.1002/jccs.202000198
• Languages: English
• ISSNs: 0009-4536

Abstract

Abstract: A new Tetrahydrofuran sesquiterpene 7, 10‐Epoxy‐10‐methy‐dodeca‐1, 6(14)‐diene‐3, 4‐diol (1 ) along with three known Tetrahydrofuran sesquiterpene compounds 2, 6, 10‐trimethyl‐2, 5:7, 10‐dioxido‐dodeca‐3, 11‐dien‐5‐ol (2 ), cis ‐hydroxydavanone (3 ), and davana acid (4 ). All isolated metabolites were tested against MCF‐7, HCT‐116, and HepG‐2 cancer cell lines. Compound 2 showed potent activity against MCF‐7 (IC50 = 26 ± 0.4 μg/ml), HCT‐116 (IC50 = 30.4 ± 0.9 μg/ml), and HepG‐2 (IC50 = 20.5 ± 0.3 μg/ml) cancer cells. Abstract : A new Tetrahydrofuran sesquiterpene (1) along with three known (2‐4) were identified from Artemisiasieberi. Compound 2 showed potent activity against MCF‐7 (IC50 = 26 ± 0.4 μg/mL), HCT‐116 (IC50 = 30.4 ± 0.9 μg/mL) and HepG‐2 (IC50 = 20.5 ± 0.3 μg/mL) cancer cells.