Linear porokeratosis with bone abnormalities treated with compounded topical 2% cholesterol/2% lovastatin ointment. Issue 1 (10th November 2020)

• Record Type: Journal Article
• Authors: Blue, Elliot; Abbott, James; Bowen, Anneli; Cipriano, Sarah D.
• Is Part Of: Pediatric dermatology. Volume 38:Issue 1(2021)
• Page Start: 242
• Page End: 245
• Publication Date: 2020-11-10
• Subjects: cholesterol -- linear porokeratosis -- lovastatin -- porokeratosis -- porokeratotic adnexal ostial nevus (PAON); Pediatric dermatology -- Periodicals; Children -- Diseases -- Periodicals; 618.925
• DOI: 10.1111/pde.14447
• Languages: English
• ISSNs: 0736-8046

Abstract

Abstract: We describe a case of linear porokeratosis with associated bone resorption in a 17‐year‐old female with marked improvement after 2% cholesterol/2% lovastatin ointment application. Porokeratosis is a heterogenous group of keratinization disorders characterized by a cornoid lamella, consisting of focal dyskeratotic cells in the granular layer and columns of parakeratosis. The pathogenesis of porokeratosis is not fully elucidated; however, germline mutations have recently been identified in the mevalonate pathway which can lead to a buildup of metabolites that could play a role in dysmaturation. There has only been one prior report of an affected distal digit with underlying bone resorption in association with linear porokeratosis.