Individual Plasmonic Nanoprobes for Biosensing and Bioimaging: Recent Advances and Perspectives. Issue 8 (1st February 2021)

• Record Type: Journal Article
• Authors: Ma, Jun; Wang, Xinyu; Feng, Jian; Huang, Chengzhi; Fan, Zhongcai
• Is Part Of: Small. Volume 17:Issue 8(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-02-01
• Subjects: advanced optical techniques -- bioimaging -- biosensing -- plasmonic nanoparticles -- single nanoparticle; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.202004287
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract: With the advent of nanofabrication techniques, plasmonic nanoparticles (PNPs) have been widely applied in various research fields ranging from photocatalysis to chemical and bio‐sensing. PNPs efficiently convert chemical or physical stimuli in their local environment into optical signals. PNPs also have excellent properties, including good biocompatibility, large surfaces for the attachment of biomolecules, tunable optical properties, strong and stable scattering light, and good conductivity. Thus, single optical biosensors with plasmonic properties enable a broad range of uses of optical imaging techniques in biological sensing and imaging with high spatial and temporal resolution. This work provides a comprehensive overview on the optical properties of single PNPs, the description of five types of commonly used optical imaging techniques, including surface plasmon resonance (SPR) microscopy, surface‐enhanced Raman scattering (SERS) technique, differential interference contrast (DIC) microscopy, total internal reflection scattering (TIRS) microscopy, and dark‐field microscopy (DFM) technique, with an emphasis on their single plasmonic nanoprobes and mechanisms for applications in biological imaging and sensing, as well as the challenges and future trends of these fields. Abstract : The usage of individual plasmonic nanoparticles (PNPs) in advanced optical techniques enables the ultrasensitive biological detection and imaging with high spatial and temporal resolution. This work comprehensively overviews the optical properties of single PNPs, the advanced optical techniques and their applications in biological sensing and imaging with single PNPs as nanoprobes, as well as the future trends of these fields.