An infant with localized vasoconstriction following topical propranolol exposure for infantile hemangioma. Issue 1 (4th December 2020)

• Record Type: Journal Article
• Authors: Saerens, Julie; Gutermuth, Jan; Janmohamed, Sherief R.
• Is Part Of: Pediatric dermatology. Volume 38:Issue 1(2021)
• Page Start: 263
• Page End: 264
• Publication Date: 2020-12-04
• Subjects: beta‐blocker -- drug reaction -- infantile hemangioma -- propranolol -- timolol; Pediatric dermatology -- Periodicals; Children -- Diseases -- Periodicals; 618.925
• DOI: 10.1111/pde.14475
• Languages: English
• ISSNs: 0736-8046

Abstract

Abstract: We describe a 3‐month‐old child with an infantile hemangioma on the forehead with a blanched macule provoked by topical treatment with propranolol. This observation demonstrates that topically applied (non‐selective) beta‐blockers may induce blanched macules at the site of application, a side effect due to peripheral vasoconstriction of blood vessels by non‐selective beta‐2 blockade. This side effect was linked due to overuse and was reversible. This case illustrates the importance of providing thorough instructions regarding topical propranolol application.