Co(III), Rh(III) & Ir(III)‐Catalyzed Direct C−H Alkylation/Alkenylation/Arylation with Carbene Precursors. Issue 5 (4th February 2021)

• Record Type: Journal Article
• Authors: Nunewar, Saiprasad; Kumar, Sanjeev; Talakola, Srilakshmi; Nanduri, Srinivas; Kanchupalli, Vinaykumar
• Is Part Of: Chemistry, an Asian journal. Volume 16:Issue 5(2021)
• Page Start: 443
• Page End: 459
• Publication Date: 2021-02-04
• Subjects: C−H activation -- carbene precursors -- migratory insertions -- Rh(III) and Ir(III) catalysts -- alkylation; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/asia.202001219
• Languages: English
• ISSNs: 1861-4728

Abstract

Abstract: Metal carbenes play a pivotal role in transition‐metal‐catalyzed synthetic transfer reactions. The metal carbene is generated either from a diazo compound through facile extrusion of N2 with a metal catalyst or in situ generated from other sources like triazoles, pyriodotriazoles, sulfoxonium ylides and iodonium‐ylide. On the other hand, Co(III), Rh(III) & Ir(III)‐catalyzed C−H functionalizations have been well established as a key synthetic step to enable the construction of various synthetic transformations. Interestingly, in recent years, merging of these two concepts C−H activation and carbene migratory insertion gained much attention, in particular group 9 metal‐catalyzed arene C−H functionalizations with carbene precursors via carbene migratory insertion. In this review, we summarize recent advances in Co(III), Rh(III) & Ir(III)‐catalyzed direct C−H alkylation/alkenylation/arylation with carbene precursors and also discuss key synthetic intermediates within the catalytic cycles. Abstract : Individually, the fields of metal carbenes and transition‐metal‐catalyzed C−H activation have become very familiar in organic synthesis. Merging these two concepts, carbene migratory insertions via C−H activation methods, are still in early stage. This review summarizes the recent advances in Co(III), Rh(III) & Ir(III)‐catalyzed direct C−H alkylation/alkenylation/arylation with carbene precursors and current developments of this emerging research area.