Development and characterization of a poly (vinyl alcohol) and sodium alginate blend foam for wound dressing loaded with propolis and all‐trans retinoic acid. Issue 21 (20th January 2021)

• Record Type: Journal Article
• Authors: Cesar, Pedro Henrique Souza; Natarelli, Caio Vinicius Lima; Oliveira, Juliano Elvis de; Andrade, Paula Ariane; dos Santos, Tamara Leite; Marcussi, Silvana
• Is Part Of: Journal of applied polymer science. Volume 138:Issue 21(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-01-20
• Subjects: biomaterials -- biomedical applications -- biopolymers and renewable polymers; Polymers -- Periodicals; Polymerization -- Periodicals; 668.9
• DOI: 10.1002/app.50480
• Languages: English
• ISSNs: 0021-8995

Abstract

Abstract: Propolis is a complex mixture of phytochemicals, with antibacterial, anti‐inflammatory, and healing properties. All ‐trans retinoic acid is implicated in wound healing by stimulating angiogenesis, cell recruitment, extracellular matrix deposition, and reepithelization. The incorporation of both agents to a polymeric wound dressing composed of poly (vinyl alcohol) and sodium alginate may result in improved healing allied to controlled release, fluid uptake, and wound protection. In the present work, we have physically characterized this wound dressing and analyzed its release kinetics. The anti‐inflammatory capacity was assayed. SEM images showed a highly porous structure with a diverse morphology. FTIR spectra displayed a highly cross‐linked structure with both polymers connected by hydrogen bonds and acetal bridges. The wound dressings were able to retain great volumes of PBS. Propolis and vitamin A releasing behavior were maintained for 6 h. The concentrations of the biologically active substances were capable of promoting anti‐inflammatory action in an erythrocyte membrane stabilization model. The wound dressings obtained here showed adequate physical properties. The fabrication process did not affect the anti‐inflammatory capacity. Further tests are needed to ensure the biocompatibility and to assess other biological activities of the therapeutic agents. Abstract : This paper discloses the development of a polymeric wound dressing comprised of poly (vinyl alcohol) and sodium alginate. We have developed an inexpensive and easy to manufacture wound dressing, able to carry and deliver biological agents to aid in wound healing. We provided the material characterization and supplemental data of the biological activities regarding the addition of propolis and all‐trans‐retinoic acid. The image displayed is the possible structure of the wound dressing.