Copper‐Based Nanoscale Coordination Polymers Augmented Tumor Radioimmunotherapy for Immunogenic Cell Death Induction and T‐Cell Infiltration. Issue 8 (1st February 2021)

• Record Type: Journal Article
• Authors: Wang, Yuxiang; Ding, Yawen; Yao, Dan; Dong, Hong; Ji, Changwei; Wu, Jinhui; Hu, Yiqiao; Yuan, Ahu
• Is Part Of: Small. Volume 17:Issue 8(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-02-01
• Subjects: immunogenic cell death -- nanoscale coordination polymers -- oxidative stress -- T‐cell infiltration; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.202006231
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract: Insufficient T‐cell infiltration seriously hinders the efficacy of tumor immunotherapy. Induction of immunogenic cell death (ICD) is a potentially feasible approach to increase T‐cell infiltration. Since ionizing radiation can only induce low‐level ICD, this study constructs Cu‐based nanoscale coordination polymers (Cu‐NCPs) with mixed‐valence (Cu + /Cu 2+ ), which can simultaneously and independently induce the generation of Cu + ‐triggered hydroxyl radicals and Cu 2+ ‐triggered GSH elimination, to synergize with radiation therapy for potent ICD induction. Markedly, this synergetic therapy remarkably enhances dendritic cell maturation and promotes antitumor CD8 + T‐cell infiltration, thereby potentiating the development of checkpoint blockade immunotherapies against primary and metastatic tumors. Abstract : The novel Cu‐based nanoscale coordination polymers (Cu‐NCPs) with mixed‐valence (Cu + /Cu 2+ ) are developed to synergize with radiation therapy for potent immunogenic death induction. Subsequently, this synergetic treatment exhibits superior therapeutic effects in inhibiting primary tumor and obviously promotes CD8 + T cell infiltration, eliciting strong antitumor immunity against distant and metastatic tumors.